Clonal Karyotype Evolution Involving Ring Chromosome 1 with Myelodysplastic Syndrome Subtype RAEB-t Progressing into Acute Leukemia
نویسندگان
چکیده
منابع مشابه
Clonal karyotype evolution involving ring chromosome 1 with myelodysplastic syndrome subtype RAEB-t progressing into acute leukemia.
Karyotypic evolution is a well-known phenomenon in patients with malignant hematological disorders during disease progression. We describe a 50-year-old male patient who had originally presented with pancytopenia in October 1992. The diagnosis of a myelodysplastic syndrome (MDS) FAB subtype RAEB-t was established in April 1993 by histological bone marrow (BM) examination, and therapy with low-d...
متن کاملCorrection: Rapidly Progressing Myelodysplastic Syndrome Initially Presenting as Acute Leukemia
[This corrects the article DOI: 10.7759/cureus.1096.].
متن کاملRapidly Progressing Myelodysplastic Syndrome Initially Presenting as Acute Leukemia
Myelodysplastic syndrome (MDS) refers to a group of various stem cell disorders, characterized by dysplastic and ineffective production in one or more cell lines. In general, MDS tends to present slowly over months to years and is commonly detected with routine bloodwork by primary care physicians. Patients may be asymptomatic and depending on age, comorbidities and risk classification of MDS m...
متن کاملFrequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.
BACKGROUND Acute myeloid leukemia is a clonal hematopoietic malignant disease; about 45-50% of cases do not have detectable chromosomal abnormalities. Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples. DESIGN AND METHODS Thirty-eight normal karyotype acute myeloid leukemia/myelodysplasti...
متن کاملComplex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report.
CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Haematologica
سال: 2006
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000093644